Porphyrin Formation in Actinic Keratosis and Basal Cell Carcinoma after Topical Application of Methyl 5-Aminolevulinate

[Studies of methyl aminolevulinate photodynamic therapy for actinic keratosis].

Photodynamic therapy (PDT) for the treatment of actinic keratosis has been shown to be effective and safe in large clinical trials published in the last 5 years. However, evidence has since emerged that raises questions or that introduces new issues, such as the management of field cancerization, fluorescence diagnosis and results in transplant recipients. There also remains a need for more stu...

Malassezia growth on peritumoral skin after routine methyl-5-aminolevulinate photodynamic therapy for actinic keratosis and nonmelanoma skin cancer.

Malassezia (Pityrosporum) species are lipophilic yeasts that are recognized as commensals of the skin of warm-blooded vertebrates. Aryl-hydrocarbon receptor (AhR) ligands produced by Malassezia species have been implicated in carcinogenesis, suggesting that this yeast may contribute to the development of skin cancer, particularly basal cell carcinoma (BCC). This hypothesis suggests that skin ca...

Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment.

BACKGROUND Actinic keratoses (AKs) are common and may progress to squamous cell carcinoma (SCC). While cryotherapy is the most commonly used treatment for AKs, it is only suitable for treating a few lesions at a time. Topical medications such as 5-fluorouracil (5-FU) allow for more generalized treatment of AKs in the setting of multiple lesions. OBJECTIVE To evaluate and discuss clinical tria...

Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma.

BACKGROUND Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. In general, the expression of A-type lamins (lamins A and C) has been correlated with a non-proliferating, differentiated state of cells and tissues. OBJECTIVES To establish and co...

Actinic Keratosis and Squamous Cell Carcinoma